Postdoctoral research fellow on CM01 in the Structural Biology Group

Job Details

The European Synchrotron, the ESRF, is an international research centre based in Grenoble, France.

Through its innovative engineering, pioneering scientific vision and a strong commitment from its 700 staff members, the ESRF is recognised as one of the top research facilities worldwide. Its particle accelerator produces intense X-ray beams that are used by thousands of scientists each year for experiments in diverse fields such as biology, medicine, environmental sciences, cultural heritage, materials science, and physics.

Supported by 21 countries, the ESRF is an equal opportunity employer and encourages diversity.

CM01 is the ESRF’s cryo-EM facility dedicated to performing high-resolution imaging of biological macromolecules, particularly for the structural analysis of large, difficult to crystallize, protein-protein or protein-nucleic acid complexes. CM01 has been designed to complement, and create synergy with, the existing ESRF macromolecular crystallography and BioSAXS beamlines and it is operated as a joint effort from the four institutes (ESRF, EMBL, IBS and ILL) located on the EPN campus. CM01 is equipped with a Krios G3 microscope and state-of-the-art K3 direct electron detector and a GATAN LS Quantum energy filter. CM01 offers single particle analysis (SPA) to users worldwide, and in the near future cryo-electron tomography (cryo-ET) as well.

The postdoctoral position available will focus on the method development in areas important for CM01 notably in SPA data analysis and cryo-ET. As for all postdoctoral researchers in the Structural Biology Group, the successful candidate will contribute to the operation of CM01 and will provide support to external users as local contact. Furthermore, the selected candidate will also participate in a research programme aimed at the structural characterization of the non-structural proteins of coronavirus and in particular of SARS-CoV2. The research project focuses on the molecular mechanisms of three non-structural proteins in viral replication by employing an integrative structural biology approach, including cryo-ET and SPA.

Further information may be obtained from Eaazhisai Kandiah (

  • PhD in biophysics, biology or closely related science obtained less than 3 years ago;
  • A strong background in cryo-EM;
  • A strong interest in method development for cryo-EM;
  • Background in structural biology and protein production is desirable;
  • Knowledge of membrane proteins is an asset;
  • Ability to interact with multi-disciplinary staff and facility users.

- Proficiency in English (working language at the ESRF)

Contract of 18 months, renewable for a further 6 or 18-month period.

Do you recognize yourself in this description? Apply now for your next professional adventure!

What we offer:

  • Be inspired by our innovative research institute, with an international workforce from 38 different countries;
  • Collaborate with global experts on real-world science;
  • Come and live in a vibrant city, in the heart of the Alps, and Europe’s Green Capital 2022;
  • Enjoy a workplace designed to support your quality of life;
  • Benefit from our competitive compensation and allowances package, including financial support for your relocation to Grenoble For further information on employment terms and conditions, please refer to

The ESRF is an equal opportunity employer and encourages applications from disabled persons.


ESRF imageThe ESRF is a landmark for fundamental and innovation-driven research, providing scientists from all over the world with the most brilliant X-rays to unveil the structure of materials and the mechanisms of life, down to atomic resolution. Our teams contribute to addressing the complex global challenges that our society faces.

Why work for us
For more than 30 years, the ESRF has enabled major scientific breakthroughs in the understanding of living and condensed matter. With its new Extremely Brilliant Source (EBS), the ESRF is opening new vistas for X-ray science, providing a growing community of scientists with unique facilities to tackle the complex global challenges facing our society. Scientific and technical interdisciplinarity are at the core of the ESRF’s success.

Training and development
The ESRF provides a unique and vibrant setting for early-career scientists, engineers and technical staff to train and develop their scientifc and technical abilities, thus driving the transfer of expertise to other research projects, to industry and to society at large. At the ESRF, we dedicate a significant part of our yearly budget to training our staff. Our human resources policy encourages internal mobility and many of our staff members have the opportunity to change jobs during their career.

Graduate schemes
The ESRF supports many initiatives and public events aimed at sharing knowledge of science and engaging with a diverse range of audiences, including school students and young children. At the heart of this mission, the ESRF offers different educational programmes for students of all levels.

Each year, the HERCULES European school, the Joint Universities Accelerator School, and the joint International Summer Student programme that we run with the Institut Laue-Langevin, offer introductory lectures and specialized courses, practical sessions, tutorials and visits to other European research facilities.

What we are looking for
We are looking for passionate and curious people who are eager to collaborate in an eminently international open environment.

We welcome people who wish to contribute to a better understanding of the world around us and to inspire and drive progress.

We welcome people in many different disciplines (e.g. science, engineering, management) who contributes, through their diversity (gender, nationality, language, culture) and their professional skills to push the frontiers of science.

Grenoble, France

Number of employees

Main areas of research
The ESRF has defined seven EBS Science goals, in line with UNESCO’s objectives for sustainable development and with the global challenges identifed by the EU’s Horizon Europe research and innovation programme:

  • Health innovation, overcoming diseases and pandemics
  • Materials for tomorrow’s innovative and sustainable industry
  • Clean energy transition, sustainable energy storage and clean hydrogen technologies
  • Planetary research and geoscience
  • Environmental and climatic challenges
  • Bio-based economy and food security
  • Humanity and world cultural heritage

Positions recently recruited for
Scientists, postdocs, PhD students, engineers, technicians, administration, management

Desired degree disciplines/class
From apprenticeship to PhD, in various disciplines (e.g. science, engineering, management, administration)

How to apply
Apply online at For further information contact

Closing date
All year round

Tel +33 04 76 88 20 19

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